Erk와 retinoic acid의 제1인두궁 패터닝 조절
Erk and retinoic acid signaling participate in the segregation and patterning of first arch derived maxilla and mandible
박은주, 탁혜진, 박은하, 백정미, Piao Zheng-Guo, 이상휘,
소속 상세정보
박은주 ( Park Eun-Ju ) - 연세대학교 응용생명공학과
탁혜진 ( Tak Hye-Jin ) - 연세대학교 응용생명공학과
박은하 ( Park Eun-Ha ) - 연세대학교 응용생명공학과
백정미 ( Baik Jeong-Mi ) - 연세대학교 응용생명공학과
( Piao Zheng-Guo ) - Jilin University Stomatological college Department of oral and maxillofacial surgery
이상휘 ( Lee Sang-Hwy ) - 연세대학교 치과대학 구강악안면외과학교실
KMID : 0360120090310020103
Abstract
In vertebrates, the face is mainly formed with neural crest derived neural crest cells by the inherent programs and the interactive environmental factors. Extracellular signaling-regulated kinase (Erk) is one of such programs to regulate the various cellular functions. And retinoic acid (RA) also plays an important role as a regulator in differentiation process at various stages of vertebrate embryogenesis. We wanted to know that the segregation as well as the patterning of maxillary and mandibular structure is greatly influenced by the maxillomandibular cleft (MMC) and the failure of this development may result in the maxillomandibular fusion (syngnathia) or other patterning related disorder. It has been well documented that the epithelium at this cleft region has significant expression of Fibroblast growth factor (Fgf)8, and it is essential for the patterning of the first arch derived structures. By the morphological, skeletal, cell proliferation and apoptotic, and hybridization analysis, we checked the effects of Erk inhibition and/or RA activation onto MMC and could observe that Erk and RA signaling is individually and synergically involved in the facial patterning in terms of FGF signaling pathway via Barx-1. So RA and Erk signaling work together for the MMC patterning and the segregation of maxillamandible by controlling the Fgf-related signaling pathways. And the abnormality in MMC brought by aberrant Fgf signaling may result in the disturbances of maxillary-mandibular segregation.
키워드
Erk;Retinoic acid;Patterning;Facial development;Maxillomandibular fusion
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